Genes and their Genotypes Comprehensive Nursing Paper Example

Genes and their Genotypes Comprehensive Nursing Paper Example

Genes and their genotypes impact how individuals react to medication or drugs. These drug-gene combinations inform medication dosing to ensure optimal response to and effectiveness of the drug (Malki & Pearson, 2019). CYP2C9, CYP2C9 3, and CYP2C9 13 polymorphisms affect irbesartan pharmacokinetics. Individuals have different CYP2C9 genotypes (12, 10, and 6 carriers of CYP2C9 1/ 1, 1/ 3, and 1/13 genotypes), which dictates their response to irbesartan. Irbesartan is an angiotensin II antagonist used to treat high blood pressure. Its significant elimination (CL) pathways entail CYP2C9 N-glucuronidation and oxidation. Therefore, an individual’s CYP2C9 genotype impacts irbesartan major elimination (Westervelt et al., 2020).(Genes and their Genotypes Comprehensive Nursing Paper Example)

Genes and their Genotypes Comprehensive Nursing Paper Example
Genes and their Genotypes Comprehensive Nursing Paper Example 1

For instance, a study found that a person with a CYP2C9*1/*3 genotype indicated 12.99 + 3.12 L/hr irbesartan major elimination compared to 21.40 + 5.98 L/hr for wild-type in persons with CYP2C9*1/*1. The drug-gene interaction decreases major elimination in people with the variant *3 type of the CYP2C9 gene (Westervelt et al., 2020). It implies that the genotype differences impact major elimination, hence the response to irbesartan because *1/*2 and *1/*3 participants indicated a greater response to the medication than *1/*1 persons, who experienced a decreased blood pressure.(Genes and their Genotypes Comprehensive Nursing Paper Example)

The study also indicates that the CYP2C9*1/*2 genotype is linked to a statistically significant elevated frequency of severe blood-pressure reduction, identified as an adverse event. The major elimination decrease leads to greater drug exposure, causing a higher-than-desired blood pressure decrease. It informs dosing because the major elimination decrease means that people with CYP2C9*1/*2 and *1/*3 need a low-maintenance dose to produce the desired pharmacological response. Additionally, individuals with CYP2C9*1/*3 and *1/*13 indicated higher maximum plasma concentration and half-lives than those with CYP2C9*1 (Westervelt et al., 2020). Persons with CYP2C9*1/*3 and *1/*13 indicated lower irbesartan oral clearance than those with *1/*1. Conclusively, CYP2C9 genetic polymorphism significantly impacted irbesartan pharmacokinetics. CYP2C9*3 and CYP2C9*13 alleles led to decreased irbesartan metabolism.(Genes and their Genotypes Comprehensive Nursing Paper Example)

See also  Bob Intelligence Assessment Report-Nursing Paper Examples

References

Malki, M. A., & Pearson, E. R. (2019). Drug–drug–gene interactions and adverse drug reactions. The Pharmacogenomics Journal20(3), 355-366. https://doi.org/10.1038/s41397-019-0122-0(Genes and their Genotypes Comprehensive Nursing Paper Example)

Westervelt, P., Cho, K., Bright, D. R., & Kisor, D. F. (2020). Drug-gene interactions: inherent variability in drug maintenance dose requirements. P & T: a peer-reviewed journal for formulary management39(9), 630–637(Genes and their Genotypes Comprehensive Nursing Paper Example).

https://www.ncbi.nlm.nih.gov/

Genes and their Genotypes Comprehensive Nursing Paper Example
Genes and their Genotypes Comprehensive Nursing Paper Example 2

A Page will cost you $12, however, this varies with your deadline. 

We have a team of expert nursing writers ready to help with your nursing assignments. They will save you time, and improve your grades. 

Whatever your goals are, expect plagiarism-free works, on-time delivery, and 24/7 support from us.  

Here is your 15% off to get started. 
Simply:

  • Place your order (Place Order
  • Click on Enter Promo Code after adding your instructions  
  • Insert your code –  Get20

All the Best, 

Cathy, CS

Have a subject expert Write for You Now

Have a subject expert finish your paper for You

Edit My Paper For Me

Have an Expert Write Your Dissertation's Chapter

What You'll Learn