{"id":264981,"date":"2024-01-10T09:01:49","date_gmt":"2024-01-10T09:01:49","guid":{"rendered":"https:\/\/nursingstudy.org\/?p=264981"},"modified":"2025-04-10T03:53:00","modified_gmt":"2025-04-10T03:53:00","slug":"genes-and-genotypes-nursing-paper-examples","status":"publish","type":"post","link":"https:\/\/nursingstudy.org\/examples\/genes-and-genotypes-nursing-paper-examples\/","title":{"rendered":"Genes and Genotypes-Nursing Paper Examples"},"content":{"rendered":"\n

Genes and Genotypes-Nursing Paper Examples<\/h2>\n\n\n\n

Genes and their genotypes impact how individuals react to medication or drugs. These drug-gene combinations inform medication dosing to ensure optimal response to and effectiveness of the drug (Malki & Pearson, 2019). CYP2C9, CYP2C9 3, and CYP2C9 13 polymorphisms affect irbesartan pharmacokinetics (Genes and Genotypes-Nursing Paper Examples). <\/p>\n\n\n

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Genes and Genotypes-Nursing Paper Examples<\/figcaption><\/figure>\n<\/div>\n\n\n

Individuals have different CYP2C9 genotypes (12, 10, and 6 carriers of CYP2C9 1\/ 1, 1\/ 3, and 1\/13 genotypes), which dictates their response to irbesartan. Irbesartan is an angiotensin II antagonist used to treat high blood pressure. Its significant elimination (CL) pathways entail CYP2C9 N-glucuronidation and oxidation. Therefore, an individual’s CYP2C9 genotype impacts irbesartan major elimination (Westervelt et al., 2020) (Genes and Genotypes-Nursing Paper Examples).<\/p>\n\n\n\n

For instance, a study found that a person with a CYP2C9*1\/*3 genotype indicated 12.99 + 3.12 L\/hr irbesartan major elimination compared to 21.40 + 5.98 L\/hr for wild-type in persons with CYP2C9*1\/*1. The drug-gene interaction decreases major elimination in people with the variant *3 type of the CYP2C9 gene (Westervelt et al., 2020). It implies that the genotype differences impact major elimination, hence the response to irbesartan because *1\/*2 and *1\/*3 participants indicated a greater response to the medication than *1\/*1 persons, who experienced a decreased blood pressure (Genes and Genotypes-Nursing Paper Examples).<\/p>\n\n\n\n

The study also indicates that the CYP2C9*1\/*2 genotype is linked to a statistically significant elevated frequency of severe blood pressure reduction, identified as an adverse event. The major elimination decrease leads to greater drug exposure, causing a higher-than-desired blood pressure decrease. It informs dosing because the major elimination decrease means that people with CYP2C9*1\/*2 and *1\/*3 need a low-maintenance dose to produce the desired pharmacological response (Genes and Genotypes-Nursing Paper Examples). <\/p>\n\n\n\n

Additionally, individuals with CYP2C9*1\/*3 and *1\/*13 indicated higher maximum plasma concentration and half-lives than those with CYP2C9*1 (Westervelt et al., 2020). Persons with CYP2C9*1\/*3 and *1\/*13 indicated lower irbesartan oral clearance than those with *1\/*1. Conclusively, CYP2C9 genetic polymorphism significantly impacted irbesartan pharmacokinetics. CYP2C9*3 and CYP2C9*13 alleles led to decreased irbesartan metabolism (Genes and Genotypes-Nursing Paper Examples).<\/p>\n\n\n\n

References<\/strong><\/h2>\n\n\n\n

Malki, M. A., & Pearson, E. R. (2019). Drug\u2013drug\u2013gene interactions and adverse drug reactions. The Pharmacogenomics Journal<\/em>, 20<\/em>(3), 355-366. https:\/\/doi.org\/10.1038\/s41397-019-0122-0<\/p>\n\n\n\n

Westervelt, P., Cho, K., Bright, D. R., & Kisor, D. F. (2020). Drug-gene interactions: inherent variability in drug maintenance dose requirements.\u00a0P & T: a peer-reviewed journal for formulary management<\/em>,\u00a039<\/em>(9), 630\u2013637.U<\/p>\n","protected":false},"excerpt":{"rendered":"

Genes and Genotypes-Nursing Paper Examples Genes and their genotypes impact how individuals react to medication or drugs. These drug-gene combinations inform medication dosing to ensure optimal response to and effectiveness…<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_wpscppro_dont_share_socialmedia":false,"_wpscppro_custom_social_share_image":0,"_facebook_share_type":"","_twitter_share_type":"","_linkedin_share_type":"","_pinterest_share_type":"","_linkedin_share_type_page":"","_instagram_share_type":"","_medium_share_type":"","_threads_share_type":"","_google_business_share_type":"","_selected_social_profile":[],"_wpsp_enable_custom_social_template":false,"_wpsp_social_scheduling":{"enabled":false,"datetime":null,"platforms":[],"status":"template_only","dateOption":"today","timeOption":"now","customDays":"","customHours":"","customDate":"","customTime":"","schedulingType":"absolute"},"_wpsp_active_default_template":true},"categories":[1],"tags":[2023,2024,1603],"class_list":["post-264981","post","type-post","status-publish","format-standard","hentry","category-nursing-paper","tag-nursing-paper-samples","tag-nursing-papers-examples","tag-topic-4-dq-1-genes-and-genotypes-nursing-paper-examples"],"_links":{"self":[{"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/posts\/264981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/comments?post=264981"}],"version-history":[{"count":3,"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/posts\/264981\/revisions"}],"predecessor-version":[{"id":276414,"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/posts\/264981\/revisions\/276414"}],"wp:attachment":[{"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/media?parent=264981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/categories?post=264981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nursingstudy.org\/examples\/wp-json\/wp\/v2\/tags?post=264981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}